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Acute Pain | Chronic Pain | General

Chelation therapy for claudication


Clinical bottom line

There is no evidence that chelation therapy with EDTA is of any value in claudication or atherosclerotic cardiovascular disease.


MD Villarruz et al. Chelation therapy for atherosclerotic cardiovascular disease. Cochrane Database of Systematic Reviews 2005 issue 4.

Systematic review


One trial had only 10 participants. In the other four there was no benefit. Two trials measured ankle-brachial pressure index and found no difference. In one trial with walking distance and pain free walking distance, there was no difference between treatment and control, by 10th or 20th infusion.


This is reasonable evidence of no effect.