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Acute Pain | Chronic Pain | General

Subcutaneous carbon dioxide insufflation for claudication


Clinical bottom line

There were few small trials, and those showed no evidence of benefit.


T Brockow et al. Clinical evidence of subcutaneous CO2 insufflations: a systematic review. Journal of Alternative Complementary Medicine 2000 6: 391-403.

Systematic review

The systematic review sought studies of any architecture and any condition, where subcutaneous carbon dioxide insufflation had been used.


There were no differences in walking distance compared with either waiting list controls or CO2 baths.


No evidence for any effect.