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Hydroquinine for RLS

Clinical bottom line

There was no evidence from one study that hydroquinine is effective for RLS.


JG van Dijk et al. Hydroquinine and placebo equally effective in the restless legs syndrome. Ned Tijdschr Geneeskd 1991 135: 759-763.

Clinical trial

This double-blind crossover trial compared hydroquinine 200 mg in the evening and before going to bed with placebo in 68 patients. The study was probably randomised, but is in Dutch, which makes this difficult to ascertain. We think it was. Duration was two weeks for each period.


There were no significant differences for any questions or outcomes.


It is highly likely that hydroquinine is without effect in RLS.