Table: Randomised, double blind controlled trials of two dextropropoxyphene compounds for acute migraine treatment
Reference Patients Design Intervention Outcomes Results (main outcomes) Quality
Hakkarainen et al 1978 Adults (women only)with at least two migraines (with or without aura) per month, DNS diagnostic criteria, patients with no or mild pain at baseline as study med taken at onset of migraine RCT, DB, CO, single dose,21 attacks, rescue medication allowed after half hour with second dose study drug, and at 2 hours with patients choice of drug 1. Dextroprpoxyphene compound (Doleron)1 to 2 tabs, n = 25 2. Aspirin 500 to 1000 mg, n = 25 3. Ergotamine tartrate 1 to 2 mg, n=25 Duration and intensity of migraine, aborting attack, effect non-pain symptoms, functional ability, use of rescue medication and adverse effects NSD between dextropropoxyphene compound and ergotamine for intensity and duration of attacks. Dextropropoxyphene significantly shorter duration and intensity than aspirin. Significantly less adverse effects with dextropropoxyphene and aspirin than ergota R=1 DB=2 W=1 Total=4
Hakkarainen et al 1980 Adults (women only) with at least two migraines (with or without aura) per month, DNS diagnostic criteria, patients with no or mild pain at baseline as study med taken at onset of migraine RCT, DB, CO, single dose,21 attacks, rescue medication allowed after half hour with second dose study drug 1. Dextroprpoxyphene compound (Doleron novum)1 to 2 tabs, n = 25 2. Ergotamine tartrate 1 to 2 mg, n=25 3. Aspirin 500 to 1000 mg, n = 25 Duration and intensity of migraine, aborting an attack, effect on nausea and vomiting, functional ability and adverse effects NSD between dextropropoxyphene compound and ergotamine for intensity and duration of attacks. Dextropropoxyphene significantly better than aspirin for intensity and duration of attacks. Adverse effects: nsd between groups for total number of adverse effe R=1 DB=2 W=0 Total=3
Abbreviations: Doleron = aspirin 350 mg, dextropropoxyphene chloride 65 mg, phenazone 150 mg, phentiazin carboxyl chloride 5 mg, caffeine 50 mg; Doleron novum = dextropropoxyphene napsylate 100 mg, aspirin 350 mg, phenazone 350 mg; RCT=randomised contro

Last Updated on 11/12/00
By Andrew Moore