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Medical therapy for pouchitis

A splendid systematic review [1] of four randomised trials in this rare chronic inflammatory disease in the ileal pouch after ileal pouch-anal anastomosis shows that metronidazole (NNT 1.6) and oral probiotic bacteria (NNT 1.2) are effective. Other treatments are not effective. The condition may be rare, but this shows how good systematic review methods can still help.


  1. 1 WJ Sandborn, R McLeod, DP Jewell. Medical therapy for induction and maintenance of remission in pouchitis: a systematic review. Inflammatory Bowel Diseases 1999 5: 33-39.

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